Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is an autoimmune liver disease characterized by immune-mediated biliary epithelial cell damage, cholestasis, and progressive fibrosis, characterized by pruritus, fatigue, and a growing awareness of mild cognitive impairment that eventually develops into biliary cirrhosis. In recent years, the incidence of autoimmune liver disease has increased significantly. Although up to 50% of patients are asymptomatic at diagnosis, present symptoms often has a significant impact on quality of life and functional status. Therefore, early detection, early detection and early treatment are especially important.