Hypertension, also known as high blood pressure, is the condition in which the pressure value of flowing blood in the vessel against the blood vessel wall is constantly higher than normal. Hypertension is often called a "silent killer", because in most patients it can have a sudden onset without any previous signs. When the blood vessel burdens pathologically high blood pressure for a long time, it can lead to severe diseases like coronary heart disease and stroke.
The combinational hypertension assessment is composed of two systems: Renin- angiotensin-aldosterone (RAAS) system: Renin, angiotensin II (AII), aldosterone (Ald) and Hypothalamo-pituitary-adrenal cortex (HPA) axis: adrenocorticotropic hormone (ACTH), cortisol.
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The panel is commonly used in the type determination of hypertension, and monitoring of the scientific medication and treatment effectiveness of hypertension patients. The assessment results can provide instructions on the proper medication for primary hypertension and allow the monitoring of treatment effectiveness, and can also be used to effectively distinguish cases of primary and secondary hypertension.Therefore, the assessment can provide scientific references for physicians to formulate reasonable antihypertensive plans for the majority of patients, evaluate the effectiveness of antihypertensive drugs currently used by the patients, and also screen out cases of secondary hypertension that are not easily detectable.
 Direct Renin Assay and Plasma Renin Activity Assay Compared .Clinical Chemistry,2004;50 (11): 2159-2161.
 Aldosterone and renin measurements [Review]. Ann ClinBiochem 2000;37:262-278.
 Direct Angiotensin II Assay and Plasma Angiotensin II Activity Assay Compared .Clinical Chemistry, 2004 ; 50 (11): 2159-2161.
 Angiotensin II and Angiotensin II measurements [Review]. Ann ClinBiochem 2000;37:262-278.
 Measurement of plasma Aldosterone:a critical review of methodology. JRAAS, 2010;11(2): 89-90.
 Yalow, R. S., S. M. Glick, J. Roth, and S. A. Berson.1964. Radioimmunoassay of human plasma ACTH.J. Clin. Endocrinol. Metab. 24: 1219.
 Measurement of plasma Cortisol:a critical review of methodology. JRAAS, 2010;11(2): 89-90.