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Rheumatoid Arthritis

Rheumatoid arthritis (RA) is an autoimmune disease with erosive arthritis as the main clinical manifestation, which can occur at any age. The pathogenesis of RA is currently unclear. The basic pathological manifestations are synovitis, pannus formation, and gradual destruction of articular cartilage and bone, which eventually leads to joint deformity and loss of function. There are many autoantibodies related to rheumatoid arthritis, such as Rheumatoid factor (RF), anti-cyclic citrullinate peptide antibody (Anti-CCP), Anti- carbamylated protein (CarP) antibodies (Anti-CarP). Among which two antibodies, RF and Anti-CCP, were written into the RA classification standards and scoring system developed by the 2010 American College of Rheumatology (ACR) and the European Union Against Rheumatism (EULAR).



Clinical Significance

Anti-CCP IgG

Cyclic citrulline polypeptide (CCP) is a group of cyclic, 10-20 amino acids, and a collection of short peptide chains containing citrulline. In RA, Anti-CCP IgG has high specificity for rheumatoid arthritis detection

Performance Characteristics



[1] Kourilovitch M, Galarza-Maldonado C, Ortiz-Prado E. Diagnosis and classification of rheumatoid arthritis[J]. Journal of autoimmunity, 2014, 48: 26-30.

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