Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective secretion of insulin, impaired biological function, or both. Diabetes is caused by the secretion or use of insulin disorders;
Insulin is the only hypoglycemic hormone secreted by pancreatic beta cells.But the concentration of C-peptide in peripheral blood is 5-10 times that of insulin, and the fluctuation is less than that of insulin.Thus the quantification of C-peptide can be more accurate to reflect the function of pancreatic beta cells.
Detection of insulin and C-peptide to evaluate islet secretion function are very important for clinical classification, disease assessment, treatment selection and prognosis judgment of diabetes.
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Insulin's response to intervention in blood glucose should be delayed before clinical symptoms appear.
Type 1 diabetes: β cells are damaged and cannot produce insulin properly.
Type 2 diabetes: insulin resistance (damage to the receptors), where sscells fail and insulin production is reduced or reduced.
Evaluation of islet function in patients is very necessary to understand the occurrence, development and prognosis of type 2 diabetes mellitus, and to make appropriate treatment plan.
Insulin testing is useful in assessing the persistence of the various effects of insulin at the start of insulin therapy
Pancreatic ss-cell tumors can produce hyperinsulinemia and lead to hypoglycemia