Gastric cancer was the fourth common cancer worldwide, and it was the second most common cause of death from cancer . Early detection is important for improving the survival rate of patients with gastric cancer (GC).
Some serum tumor markers including alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, CA50, and CA72-4 have been reported to be elevated in some patients with gastric cancer [2–4].
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Rising AFP levels may also be detected in the malignant tumors of various organs, including the stomach, lung, pancreas, colon, bladder and ovary.[5–11]
In advanced or recurrent gastric cancer, the estimation of either CA 19-9 or CA-50 and CEA serum values may help in checking the prognosis, determining the efficacy of palliative treatment modalities, and recognizing recurrences. 
CA72-4 is highly sensitive to gastric cancer, and the positive rate of serum CA72-4 in gastric cancer is reported to be 36% to 94%. And its specificity is also high, some of which even reach 100%.CA72-4 can be used to detect whether there are residual tumor cells after operation and judge the prognosis of gastric cancer.
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