Cervical cancer is the fourth most frequently diagnosed cancer and the fourth leading cause of cancer death in women. Human papillomavirus (HPV) is a necessary but not sufficient cause of cervical cancer. Other important cofactors include some sexually transmittable infections (HIV and Chlamydia trachomatis), smoking, a higher number of childbirths, and long-term use of oral contraceptives.
For squamous cell cervical cancer, squamous cell carcinoma antigen (SCC) is the marker of choice. Carcinoembryonic antigen (CEA) and CA 125 have demonstrated possible utility in patients with cervical adenocarcinoma. 
Serum concentrations of SCC have been found to correlate with tumor stage, tumor size, residual tumor after treatment, recurrent or progressive disease, and survival in patients with squamous cell cervical cancer.
Pre-treatment CA 125 levels are raised in 20-75% of patients with cervical adenocarcinoma, and reflect tumour stage, tumour size, histological grade, cervical stromal invasion, lymph-vascular space status and lymph node status. Pre-treatment CA 125 levels appear to have a prognostic value, and rising serum CA 125 during follow-up may precede or be coincident with the clinical diagnosis of recurrent cervical adenocarcinoma. 
The preoperative serum levels of CEA and CA125 might have significant prognostic implications in early-stage ADC patients. Combined preoperative serum CEA and CA125 levels independently predicted the prognosis of early-stage ADC.
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